OurVision
LabMembers
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Csaba Sőti
soti.csaba@med.semmelweis-univ.hu
Principal Investigator, Associate Professor
Curriculum Vitae -
Minh Tú Nguyen, DMD
minhtu.nguyen@med.semmelweis-univ.hu
Assistant LecturerResearch interest: Identification of novel Hsp90 clients
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Dávid M. Gyurkó, MD
gyurko.david@med.semmelweis-univ.hu
Graduate StudentResearch interest: Characterization of novel genes in learning and memory (in C. elegans)
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Milán Somogyvári
somogyvari.milan@med.semmelweis-univ.hu
Biologist, Graduate StudentResearch interest: The role of Hsp90 in the stress response and ageing of the roundworm C. elegans
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Beatrix Gilányi
dgilanyib@gmail.com
Technician, Lab ManagerResearch interest: Cell cultures
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Iván Fekete
baulde@gmail.com
Medical Student, Research AssociateResearch interest: Hsp90 related protein networks
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Zoltán Pathó
pathozoli@gmail.com
Chemistry Student, Research AssociateResearch interest: Determination of the stress-induced extracellular Hsp70 response
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István Taisz
istvan.taisz@gmail.com
Medical Student, Research AssociateResearch interest: Regulation of the heat shock response in C. elegans
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Bence Tihanyi
tihanyibene@gmail.com
Medical Student, Research AssociateResearch interest: Characterization of somatomental responses to stress
Former members:
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Alper Arslan, PhD
Molecular and cell biologistAssistant Professor in Department of Medical Biology, Ondokuz Mayıs University, Samsun, Turkey
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Diána Papp, PhD
BiologistMaternity leave
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Zoltán Spiró
BiologistCurrent position: grad student in Gönczy-lab, EPFL, Lausanne, Switzerland
Selected
Publications
Original papers
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Sőti C, Rácz A,
Csermely P. (2002) A nucleotide-dependent molecular switch controls
ATP binding at the C-terminal domain of Hsp90: N-terminal nucleotide
binding unmasks a C-terminal binding pocket. J Biol Chem.
277:
7066-7075. Download in PDF
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Burnett C, Valentini S, Cabreiro
F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Stutphin GL, Leko
V, McElwee JJ, Vazquez-Manrique RP, Orfila A-M, Ackerman D, Au C,
Vinti G, Riesen M, Howard K, Neri K, Bedalov A, Kaeberlein M, Sőti
C, Partridge L, Gems D. (2011) Absence of effects of Sir2
overexpression on lifespan in C. elegans and Drosophila. Nature
477: 482-485. Download in PDF
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Arslan MA, Chikina M, Csermely
P, Sőti C. (2012) Misfolded proteins inhibit proliferation
and promote stress-induced death in SV40-transformed mammalian
cells. FASEB J. 26: 766-777. Download in PDF
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Papp D, Csermely P, Sőti C.
(2012) A role for SKN-1/Nrf in pathogen resistance and
immunosenescence in Caenorhabditis elegans. PLoS Pathog.
8: e100267. Download in PDF
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Spiró Z, Arslan MA, Somogyvári
M, Nguyen MT, Smolders A, Dancsó B, Németh N, Elek Z, Braeckman B,
Csermely P, Sőti C. (2012) RNA interference links oxidative
stress to the inhibition of heat stress adaptation. Antiox. Redox
Signal. 17: 890–901. Download in PDF
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Nguyen MT, Csermely P, Sőti C (2013) Hsp90 chaperones PPARγ and regulates differentiation and survival of 3T3-L1 adipocytes. Cell Death Differ. 20:1654-1663. Download in PDF
EDITORIAL HIGHLIGHT. Download in PDF
Reviews and hypotheses
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Sőti C, Csermely P.
(2003) Ageing and molecular chaperones. Exp. Gerontol. 10:
1037-1040. Download in PDF
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Sőti C, Pál C, Papp B,
Csermely P. (2005) Molecular chaperones as regulatory elements of
cellular networks. Curr. Opin. Cell
Biol. 17:210-215. Download in PDF
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Sőti C, Nagy E, Giricz
Z, Vígh L, Csermely P, Ferdinándy P. (2005) Heat shock proteins as
emerging therapeutic targets. Br. J. Pharmacol. 146:
769-780. Download in PDF
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Kiss HJM, Mihalik Á, Nánási
T, Őry B, Spiró Z, Sőti C, Csermely P. (2009) Ageing as a
price of cooperation and complexity: self-organization of complex
systems causes the ageing of constituent networks. Bioessays
31: 651-664. Download in PDF
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Dancsó B, Spiró Z, Arslan MA,
Nguyen MT, Papp D, Csermely P, Sőti C. (2010) The heat shock
connection of metabolic stress and dietary restriction. Curr.
Pharm. Biotechnol. 11: 139-145. Download in PDF
- Gyurkó D, Sőti C, Steták A, Csermely, P. (2013) System level mechanisms of adaptation, learning, memory formation and evolvability: the role of chaperone and other networks. Curr. Prot. Pept. Sci. in press