A fundamental attribute of living organisms is the continuous adaptation to environmental change (stress) – from a single cell through intercellular communication to neuronal and mental structures. What mechanism ensures our integrity, balance and well-being in every possible sense? How do we lose our balance, resulting in devastating diseases? How could we extend our integration and healthspan to older age? To decipher these fascinating questions, we investigate various manifestations of this mechanism, so called ’stress responses’ that are able to sense and respond to stresses. Moreover, we also focus on how diverse stresses and stress responses are integrated into a single complex adaptive response and how this adaptation is altered in aging and various pathological conditions. Finally, we study evolutionary conserved molecular mechanisms of neurobehavioral adaptation: learning and memory formation. Our experiments utilize bioinformatics and network analysis, proteins, mammalian cells, the small roundworm Caenorhabditis elegans and specimens from human volunteers. Our research will increase our understanding of adaptive responses, may open new therapeutic avenues and help promote more robust, extended health.


Former members:


Original papers

Reviews and hypotheses

Csaba Sőti's Full List of Publications